hrp0094p1-105 | Adrenal B | ESPE2021

The genetic etiology of ACTH-dependent aldosterone hypersecretion in hypertensive patients without Primary Aldosteronism

Mourtzi Niki , Sertedaki Amalia , Markou Athina , Piaditis Georgios , Katsanis Nicholas , Traeger-Synodinos Joanne , Tsigos Constantinos , Charmandari Evangelia ,

Introduction: Compelling evidence suggests that Primary Aldosteronism (PA) is much more prevalent than previously thought, accounting for more than 20% of patients with resistant hypertension. Although, major advances have been made in the field of genetics underpinning sporadic and familial forms of PA, the etiology of mild forms of PA is poorly understood. In previous studies, we identified a distinct cohort of patients without PA who exhibited ACTH-dependen...